Plasma fatty acids and primary open-angle glaucoma in the elderly: the Montrachet population-based study

Abstract Background To compare plasma fatty acids (FAs) between participants with primary open-angle glaucoma (POAG) and without neuropathy in an elderly population to investigate specific FAs pattern POAG. Methods We conducted a population-based study older than 75 years. Participants underwent comprehensive eye examination optic nerve photographs, visual field test OCT RNFL thickness measurement. Glaucomatous status was defined according the International Society for Epidemiologic Geographical Ophthalmology classification. Lipids were extracted from methylesters prepared analyzed by gas chromatography-mass spectrometry. Results Among 1153 of Montrachet 810 retained analysis 68 had The mean age 82.11 ± 3.67. In multivariable levels not different POAG controls ( P = 0.078). A characterized high negative weight gamma-linoleic acid, eicosapentaenoic acid polyunsaturated (PUFAs), Cis-7 hexadecenoic monounsaturated (MUFAs) positive eicosadienoic docosatetraenoic docosapentaenoic n-6, alpha linoleic PUFAs, eicosenoic MUFAs, margaric behenic saturated positively associated After adjustment major confounders, individuals upper tertile scores compared those lower more likely present (OR 3.09 [95% CI 1.29–7.40] 0.013). Conclusions found no significant difference regarding isolated but might be